identification of xq22.1-23 as a region linked with hereditary recurrent spontaneous abortion in a family

background:   objective: in this study we performed linkage analysis on a large x linked rsa pedigree to find a novel susceptibility locus for rsa.   materials and methods: a linkage scan using 11 microsatellites was performed in 27 members of a large pedigree of hereditary x-linked rsa. two point parametric linkage was performed using superlink v 1.6 program. results: evidence of linkage was observed to markers at xq23, dxs7133 and at xq22.1 dxs101, with lod score of 3.12 and 1.60, respectively. conclusion: identified locus in this study may carry a responsible gene in rsa. narrowing down of this region may leads to identification of this gene recurrent spontaneous abortion (rsa) is one of the most common health complications with a strong genetic component. several genetic disorders were identified as etiological factors of hereditary x linked rsa. however, more genetic factors remain to be identified.